In Vitro & In Vivo Models for Translational Research

Moderated by Rony Avritscher, MD, FSIR and Terence P. Gade, MD, PhD 

• Opening Remarks & Masterclass Overview, presented by Rony Avritscher, MD, FSIR
• How to Start a Lab and Negotiate Your Package: the Story of the PIGI Lab, presented by Terence P. Gade, MD, PhD
• Rodent Models in Interventional Oncology: Unlocking Mechanisms and Enabling High-Throughput Hypothesis Testing, presented by Khashayar Farsad, MD, PhD
• Large Animal Models in Interventional Oncology: Bridging the Gap to Clinical Application and Advancing Device Development presented by Luke R. Wilkins, MD, FSIR

Cellular & Molecular Mechanisms

Moderated by Lynn J. Savic, MD and S. Nahum Goldberg, MD, FSIR, FCIRSE

• 2D and 3 D Culture Models: Applications in Testing Combination Approaches, presented by Glauco Souza, MD
• Immunological Consequences of Thermal Ablation & Endovascular Therapy, presented by Lynn J. Savic, MD
• Potentiating the Efficacy of Endovascular Locoregional Therapy: Enabling Synergy and Overcoming Resistance, presented by Christopher D. Malone, MD
• Roundtable Discussion: Bridging the Preclinical-Clinical Divide, facilitated by S. Nahum Goldberg, MD, FSIR, FCIRSE, in conversation with Khashayar Farsad, MD, PhD, Bradford J. Wood, MD, and Lynn J. Savic, MD

Clinical Trials in Interventional Oncology (Part 1)

Moderated by Michael C. Soulen, MD, FSIR, FCIRSE and Irene Bargellini, MD, Prof

• From Bench to First-in-Human: Navigating the Regulatory Landscape presented by Kristy Brock, MD
• Endpoints That Matter: Selection of Clinically Meaningful Outcomes in IO Trials, presented by Michael C. Soulen, MD, FSIR, FCIRSE
• Statistical Considerations for IO-Specific Trial Designs
• Roundtable Discussion: Addressing Challenges in IO Trial Design, facilitated by Michael C. Soulen, MD, FSIR, FCIRSE, in conversation with Irene Bargellini, MD, Prof, and Richard Finn, MD

Clinical Trials in Interventional Oncology (Part 2)

Moderated by Jens Ricke, MD and Philippe L. Pereira, MD 

• Rational Design of IO-Immunotherapy Combinations, presented by Jens Ricke, MD
• Theranostic Approaches: Combined Diagnostic and Radioembolization, presented by Liliana Violante, MD
• Critical Gaps in Clinical Data: Looking Toward the Future, presented by Amy Deipolyi, MD, PhD, FSIR
• Roundtable Discussion: Evolving Trial Evidence and Clinical Practice Changes, facilitated by Jens Ricke, MD, in conversation with Amy Deipolyi, MD, PhD, FSIR, Philippe L. Pereira, MD, and Michael C. Soulen, MD, FSIR, FCIRSE

Industry Developments and Innovation Pipeline

Moderated by Isabel G. Newton, MD, PhD, Julius Chapiro, MD, PhD, and Muneeb Ahmed, MD, FSIR 

• Abscopal Effects: Facts and Fiction, presented by Isabel G. Newton, MD, PhD
• Integrating machine learning into future trials for Embolotherapies, presented by Julius Chapiro, MD, PhD
• The Role of LRT in Emerging Biological Therapies for Cancer, presented by Jason Chiang, MD, PhD
• Trial Failures: What Have We Learned? presented by Jens Ricke, MD
• Roundtable Discussion: Clinical Integration of Novel Technologies, presented by Muneeb Ahmed, MD, FSIR
• Roundtable Discussion: From Concept of Commercialization, presented by Glauco Souza, MD