Cryoablation and the Immune System: What We Need to Know for Clinical Practice

CME Information

Activity Title Cryoablation and the Immune System - What We Need to Know for Clinical Practice
Topic Cryoablation in interventional oncology
Accreditation Type AMA PRA Category1 Credit(s)
Release Date November 1, 2020
Expiration Date November 30, 2021
Estimated Time to Complete Activity 60 minutes


  • Understand current practice patterns and applications of cryoablation in a variety of cancer
  • Appreciate the complexity of currently available clinical trial and basic science data
  • Identify potential use cases for cryoablation as well as gauge limitations of the technique


Image guided cryoablation is a guideline approved and widely accepted therapeutic option for primary renal, lung and liver cancer as well as for oligo-metastatic disease to the bone and soft tissues. With the recent advent and growing interest in immunotherapy in solid tumors, possible synergistic effects of such therapies with cryoablation have been widely discussed and are currently under investigation. Specifically, cryoablation is thought to play a special role among all ablation modalities with respect to its ability to stimulate antigen exposure to the immune system and improve abscopal immune response. This activity is developed to educate clinicians on the most cutting edge research and possible novel applications of cryoablation in combination with immunotherapy for all of the aforementioned malignancies.


Matthew Callstrom, MD, PhD | Mayo Clinic

Muneeb Ahmed, MD | Beth Israel Deaconess Medical Center


Isabel Newton, MD, PhD | University of California San Diego

Stephen Hunt, MD, PhD, DABR | University of Pennsylvania

Nariman Nezami, MD | Emory University

Andrew J. Gunn, MD | The University of Alabama at Birmingham


Jointly provided by The France Foundation and The Society of Interventional Oncology:



This activity is intended for interventional radiologists, hepatologists, radiation, medical and surgical oncologists, transplant surgeons, and physicists who treat patients with hepatic malignances.


This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of The France Foundation and The Society of Interventional Oncology. The France Foundation is accredited by the ACCME to provide continuing medical education for physicians.



The France Foundation designates this internet live course for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This credit will be free to SIO members.


In accordance with the ACCME Standards for Commercial Support, The France Foundation (TFF) and The Society of Interventional Oncology (SIO) require that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. TFF and SIO resolve all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all their educational programs. Furthermore, TFF and SIO seek to verify that all scientific research referred to, reported, or used in a CME/CE activity conforms to the generally accepted standards of experimental design, data collection, and analysis. TFF and SIO are committed to providing learners with high-quality CME/CE activities that promote improvements in health care and not those of a commercial interest.



The planners, reviewers, editors, staff, CME committee, or other members at The France Foundation who control content have no relevant financial relationships to disclose.

The planners, reviewers, editors, staff, CME committee, or other members at The Society of Interventional Oncology who control content have no relevant financial relationships to disclose.



The following faculty report that they have relevant financial relationships to  disclose:

  • Dr. Matthew Callstrom has consulted (non-CE) for Varian and Medtronic. He serves as contract researcher for Galil Medical.
  • Dr. Isabel Newton has consulted (Non-CE) for Boston Scientific and Varian
  • Dr. Stephen Hunt has served on speakers bureau and consulted (non-CE) for Boston Scientific. He serves at contract researcher for Guerbet, BTG, and NIH. Dr. Hunt holds property rights/patent holder for PIGILab Research Ventures and is involved with the startup company Artificial Intel Med Imaging Enterprise (AIMIE).
  • • Dr. Andrew J. Gunn has consulted (Non-CE) for Boston Scientific and Varian. He serves on speakers bureau for Terumo and Boston Scientific. Dr. Gunn serves as contract researcher for Penumbra.

The faculty listed below report that they have no relevant financial relationships to disclose:

  • Dr. Muneeb Ahmed
  • Dr. Nariman Nezami



This activity is supported by an educational grant from Boston Scientific Corporation.



TFF and SIO require CME faculty (speakers) to disclose when products or procedures being discussed are off label, unlabeled, experimental, and/or investigational, and any limitations on the information that is presented, such as data that are preliminary, or that represent ongoing research, interim analyses, and/or unsupported opinion. Faculty in this activity may discuss information about pharmaceutical agents that is outside of US Food and Drug Administration approved labeling. This information is intended solely for continuing medical education and is not intended to promote off-label use of these medications. TFF and SIO do not recommend the use of any agent outside of the labeled indications. If you have questions, contact the Medical Affairs Department of the manufacturer for the most recent prescribing information.


The France Foundation and The Society of Interventional Oncology present this information for educational purposes only. The content is provided solely by faculty who have been selected because of recognized expertise in their field. Participants have the professional responsibility to ensure that products are prescribed and used appropriately on the basis of their own clinical judgment and accepted standards of care. The France Foundation, The Society of Interventional Oncology, and the commercial supporter assume no liability for the information herein.


Copyright © 2020 by The Society of Interventional Oncology. Any unauthorized use of any materials on the site may violate copyright, trademark, and other laws. You may view, copy, and download information or software ("Materials") found on the Site subject to the following terms, conditions, and exceptions:

  • The materials are to be used solely for personal, noncommercial, informational and educational purposes. The materials are not to be modified. They are to be distributed in the format provided with the source clearly identified. The copyright information or other proprietary notices may not be removed, changed, or altered.
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Technical Requirements:

  1. There are no fees for participating in and receiving credit for this activity as an SIO member.
  2. Review the activity objectives and CME/CE information.
  3. Complete the CME/CE activity
  4. Complete the CME/CE evaluation/attestation form, which provides each participant with the opportunity to comment on how participating in the activity will affect their professional practice; the quality of the instructional process; the perception of enhanced professional effectiveness; the perception of commercial bias; and his/her views on future educational needs.
  5. Credit documentation/reporting:
    • If you are requesting AMA PRA Category 1 Credits™ or a certificate of participation—your CME/CE certificate will be available for download.
  6. To request credit, you must complete the webinar in its entirety


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SIO Member Instructions

Please email education@sio-central for instructions on how to receive your CME Credits.

SIO Non-Member Instructions

Please follow the instructions below:

  1. Click here to log into your SIO online account *
  2. Click here and add your Cryoablation Webinar CME credits to your shopping cart
  3. In the lower right corner of the webpage, click "add to cart"
  4. In the upper left corner of the webpage, click "view cart"
  5. Click "checkout"
  6. Review your billing information and click "OK"
  7. Complete your payment using your preferred payment method
  8. You will receive a confirmation email containing final instructions for obtaining your CME credits

* If you do not already have an SIO online account, you can create your free guest account by clicking here.


If you have questions about this CME activity, please contact The France Foundation at 860-434-1650 or