A Roundtable Discussion on the Multicenter LEGACY Study: Response Rate, Duration of Response and Overall Survival of Y90 in Early and Advanced HCC

CME Information

Activity Title A Roundtable Discussion on the Multicenter LEGACY Study: Response and Overall Survival of Y90 in Early and Advanced HCC
Topic Y90 in early and advanced HCC
Accreditation Type AMA PRA Category1 Credit(s)
Release Date October 1, 2020
Expiration Date October 31, 2021
Estimated Time to Complete Activity 90 minutes


  • Discuss the objective response rates when assessed using blinded independent central review
  • Discuss the importance of duration of response
  • Review overall survival observed in early and advanced HCC
  • Synthesize how data from this study can impact clinical outcomes for patients with HCC


Hepatocellular carcinoma (HCC) both primary and secondary affects millions of patient worldwide. While early stage disease might be amenable for curative treatments, chemotherapy is used for the majority of other cases. Due to the lack of effective systemic therapies for HCC, researchers have been investigating the use of locoregional tumor control with Yttrium-90 (Y90) radioembolization. Currently, there are two approved available Y90 devices for administration and numerous ongoing trials aimed at exploring the current and future utility of radioembolization in hepatic malignancies. As more information from studies are made available it is important to ensure clinicians are up to date with the latest evidence.  This activity is developed to educate clinicians on newer evidence and how to apply the information to their current practice of treating patients with hepatic malignancies.


Riad Salem, MD, MBA
Professor of Radiology, Medicine, and Surgery Chief, Section of Vascular and Interventional Radiology
Vice-Chair, Image-Guided Therapy
Department of Radiology
Northwestern University


Guy Johnson, MD
Radiologist and Associate Professor of Radiology
University of Washington

Ed Kim, MD, FSIR
Associate Professor of Radiology and Surgery
Director, Interventional Oncology
Department of Radiology, Division of Interventional Radiology
Mount Sinai Health Systems

Siddarth Padia, MD
Specialist, Vascular and Interventional Radiology
Radiological Sciences Department

Uei Pua, MBBS
Senior Consultant
Tan Tock Seng Hospital


Jointly provided by The France Foundation and The Society of Interventional Oncology:



This activity is intended for interventional radiologists, hepatologists, radiation, medical and surgical oncologists, transplant surgeons, and physicists who treat patients with hepatic malignances.


This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of The France Foundation and The Society of Interventional Oncology. The France Foundation is accredited by the ACCME to provide continuing medical education for physicians.



The France Foundation designates this internet live course for a maximum of 1.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This credit will be free to SIO members.


In accordance with the ACCME Standards for Commercial Support, The France Foundation (TFF) and The Society of Interventional Oncology (SIO) require that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. TFF and SIO resolve all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all their educational programs. Furthermore, TFF and SIO seek to verify that all scientific research referred to, reported, or used in a CME/CE activity conforms to the generally accepted standards of experimental design, data collection, and analysis. TFF and SIO are committed to providing learners with high-quality CME/CE activities that promote improvements in health care and not those of a commercial interest.



The planners, reviewers, editors, staff, CME committee, or other members at The France Foundation who control content have no relevant financial relationships to disclose.

The planners, reviewers, editors, staff, CME committee, or other members at The Society of Interventional Oncology who control content have no relevant financial relationships to disclose.



The following faculty report that they have relevant financial relationships to  disclose:

  • Riad Salem has consulted (non-CE) for Boston Scientific, Cook, Eisai, AstraZeneca, Sirtex, and Genentech. He has contracted research for Boston Scientific.
  • Edward Kim has consulted (non-CE) for Boston Scientific and Bristol Myers Squibb. He has served on Speakers Bureau (non-CE) for Ethicon Neuwave and Boston Scientific. Dr. Kim has contracted research for Philips Healthcare.
  • Siddarth Padia has consulted (non-CE) for Boston Scientific and has contracted research for Varian Medical Systems. Dr. Guy Johnson has consulted (non-CE) for Boston Scientific and Genentech.

The faculty listed below report that they have no relevant financial relationships to disclose:

  • Uei Pua



This activity is supported by an educational grant from Boston Scientific Corporation.



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Technical Requirements:

  1. There are no fees for participating in and receiving credit for this activity as an SIO member.
  2. Review the activity objectives and CME/CE information.
  3. Complete the CME/CE activity
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