Research & Grants


Call for Research Grant Applications:Transarterial Chemoembolization and Immuno-Oncology

The SOCIETY OF INTERVENTIONAL ONCOLOGY is pleased to announce a call for research proposals on the combined topics of transarterial chemoembolization with lipiodol and immuno-oncology, which has been generously sponsored by Guerbet LLC. These grants are designed to fund a research evaluating and advancing the interactions between two premier interventional oncologic therapies.

Examples of the types of projects this initiative could support but is not limited to include:

  • Pre-clinical studies that improve molecular biologic understanding of lipiodol’s interaction with the immune system within tumors or the liver.
  • Innovative imaging and technical approaches in liver cancer using lipiodol including potentialization combined with immuno-oncologic therapies.
  • Serologic and / or tissue and / or imaging biomarker studies linked to improving prediction of patient outcomes for lipiodol TACE when combined with immuno-oncologic approaches.
  • Pre-clinical and clinical studies combining TACE with immunotherapies in primary or secondary liver cancer

Applicants should propose innovative research that advances the fields of interventional oncology, transcatheter tumor therapy, and immuno-oncology. Preliminary data are not required, but encouraged. High quality applications that address this solicitation will be given special consideration. This is a high priority mechanism and proposals that describe short time-lines for completion of the study and dissemination of results will be preferred.


Grant funding of up to $50,000 for one year exploratory pilot projects and up to $100,000 for larger one to two year projects with preliminary data will be provided. If the grant proposal represents supplemental funding to existing projects clear justification for additional funding must be provided.


Grants are available to full-time interventional radiology faculty and trainees with an MD, DO, PhD, or equivalent degree. Post- doctorate candidates are invited to apply. Collaboration between an interventional oncologist and field experts having documented experience in immunotherapy and / or basic research in tumor immunology / biology are required.  Likewise, full-time immuno-oncologists and basic researchers are encouraged to apply – provided that documented collaboration with an interventional oncologist.

It is anticipated that at least one of the successfully funded applicants will be or become a member of the Society of Interventional Oncology (SIO). The transfer of the second and third milestone payment is conditioned to the annual SIO meeting attendance of the funded investigator which includes an oral presentation of the preliminary data during the dedicated grant sessions.


The application must contain a detailed research plan and a one to two year budget for the planned research with all other funding sources indicated.

A letter from the department chair (for faculty applicants) or fellowship director (for trainee applicants) must be provided that indicates approval of application, comments on the merit of the project, and explains the extent to which the department is supporting the applicant’s research in terms of funding and/or available facilities. It is important that the letter indicate commitment to provide protected research time and support the salary of the applicant during the research period. 


The application must be submitted electronically through the online application found here. 

The deadline for this announcement is 31 December 2019. Applications must be submitted in PDF format. Incomplete applications and those submitted after the deadlines will not be reviewed.

All the items detailed below must be included in the application before it will be considered.

  1. Cover Letter: Application must submit a one page letter detailing the relevance and significance of this proposal to furthering the goals of both interventional oncology and immuno-oncology.
  2. Title Page: Applicant must submit a one page lay statement of proposed project including individual contact information, brief abstract, beginning and termination dates of proposed research.
  3. Research Strategy / Specific Aims (1 page limit)
  4. Detailed Proposal: Limited to 10 pages of text, plus one page of preliminary data in the form of, tables, charts, and figures, and one page of references. (Please further note that banking / registry studies will require a documented plan for maintenance of resource beyond the funding period.)
  5. Budget Proposal: List budget items in appropriate categories and give details and justification of each item in each category, including requests for materials from Guerbet, LLC. 
  6. Supporting Documents:
  • Biographical Sketch of all principle and co-investigators (NIH format)
  • Letter from Department Chair
  • IACUC and/or IRB approval if already granted



Budget expenses can be used for materials and supplies, data and data analysis costs, salaries for research assistants working on the proposed project, publication costs, as well as reasonable time for the principal investigator. A portion of the budget can be allocated for salary support of the collaborators and/or consultants. Travel expenses, institutional indirect/overhead costs, construction expenses, and secretarial or office expenses will not be funded.


Applications are judged on merit and grants may be allocated until the funding allocation for this announcement is reached.

Completed applications will be distributed to the members of the SIO special study-section and, and members will be assigned as primary reviewers based on their expertise in the particular area of the proposed investigation. Funding decisions will be made and approved by the SIO Grant Review Committee. Applicants will be notified of application status upon final funding decisions, anticipated by 31 January 2020. 

Funding decisions are based on the overall impact/priority score which reflect assessment of the likelihood for the project to exert a sustained, powerful influence on the fields of interventional and immuno-oncology based on the following review criteria and additional review criteria:

  1. Significance to Interventional Oncology. Does the project combine transcathether embolic techniques with immuno-oncology to address an important problem or a critical barrier to progress in the field? If the aims of the project are achieved, how will this research impact outcomes for both interventional oncology and immuno-oncology?
  2. Innovation. Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed?
  3. Approach. Are the overall strategy, methodology, and analyses well-reasoned and appropriate to accomplish the specific aims of the project? Are potential problems, alternative strategies, and benchmarks for success presented? If the project is in the early stages of development, will the strategy establish feasibility and will particularly risky aspects be managed?
  4. Investigator. Are the PI, collaborators, and other researchers well suited to the project? If Early Stage Investigators or New Investigators, or in the early stages of independent careers, do they have appropriate experience and training or appropriate mentors/collaborators? If established, have they demonstrated an ongoing record of accomplishments that have advanced interventional radiology?
  5. Environment. Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?


In addition, the review committee will take the following factors into consideration as applicable to the proposed project:

Budget and Period of Support. Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.

Letters of support. Letters of support from industry and/or memorandums of understanding with collaborators will be taken into consideration.


Once grant agreements and documentation of IRB and/or IACUC approval have been submitted by successful applicants, awarded funds will be transmitted to the institution for support of the grant recipient and the project. Funds will be distributed in three installments: 40% at the start of the project, 30% upon receipt of the six- month progress report, and 30% upon receipt and approval of a cover letter and the final report in manuscript format.


This is a rapid high priority award mechanism. An interim progress report is required after the first 6 months of the project. A final report is required no later than 12 months after the award is made. This report should be a one- page synopsis of the progress, unforeseen problems, and results to date. A final written report must be submitted within sixty (60) days of the project’s completion. Included with the report should be a cover letter that:

  1. Indicates the significance/possible impact of the results; 
  2. States whether the results will be submitted for possible publication, and if so, to what journal; 
  3. Indicates whether results will be used to apply for additional funding from other sources, and if so, the funding agency and date of application should be included



Presentation of research results at the SIO Annual Scientific Meeting in a highlighted research session will be required.

All posters, oral presentations, and eventual publications must contain appropriate acknowledgement of the SIO and Guerbet, LLC support.



Cost Extensions for both one year pilot grants and 1 – 2 year larger grants are discouraged, but will be reviewed on a case by case basis.


SIO reserves the right to modify or terminate the amount of any funds granted under the terms of the Research Grant. Generally, such action would be based on the awardee’s receipt of support from sources other than SIO which might (1) limit the ability of the recipient to successfully complete the terms of the award or (2) obviate the recipient’s need for funding from SIO.

In the event that the awardee relocates to a different institution, a request in writing to relocate the grant to the new institution may be made to the Director of Research at the Foundation’s address. The SIO will continue project funding provided the awardee is guaranteed support, protected research time, and adequate equipment/facilities from the new institution (i.e., letter from department chair) as well as IRB or IACUC approvals, if applicable. If the new institution cannot provide the necessary support or regulatory approvals for the project, the original institution may appoint a new principal investigator, with SIO’s approval, to complete the project. If the project cannot be completed at the new or the original institution, then all unexpended funds must be returned to SIO.

Proposals must be submitted by Tuesday, 31 December 2019 at 11:59 pm EST. 

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